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GSI's proprietary bioscaffold actv-graft™ helps the body regenerate its own tissues while inherently mitigating infection.
actv-graft™ provides biomechanical and biomolecular cues for tissue regeneration that meet patient-specific functional needs.
Restoring Tissue Form & Function
Existing tissue reconstructive systems such at porous polyethylene seek to restore anatomical form and position but are permanent and unnaturally rigid. They can also become encapsulated by fibrous tissue that excludes proper integration and can lead to infection and loosening risk long term.
actv-graft™ reliably facilitates tissue attachment, integration, regeneration with adjunct biomechanically-tuned support. After granulation tissue matures to a competent level for the target tissue type actv-graft™ bioresorbs as water, carbon dioxide and bioavailable silica - a vital nutrient for the body.
Patient Specific Implants
actv-graft™ has been developed to be rapidly 3D print-formed using our proprietary PSI™ method during surgery. The bioscaffold can also be further adjusted, shaped, or simply cut from block or sheet and sutured or screw-anchored as per surgeon preference. Current applications under development with our surgeon team include cranial, spine, spinal disk, ear and nose.
Our PSI™ methods have already been successfully used in the clinic to deliver patient specific implants for skull and spine reconstruction using systems that have been found to inhibit infection better than 3D printed and PEEK in vitro. The digitally rendered PSI™ implant or guidance tools practically assist surgical process and implant positioning by nature of pre-defined datum lines and anchor points.
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